ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis
ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for
regulating leukocyte recruitment from circulation to sites of inflammation. However, in …
regulating leukocyte recruitment from circulation to sites of inflammation. However, in …
Update on neutrophil function in severe inflammation
Neutrophils are main players in the effector phase of the host defense against micro-
organisms and have a major role in the innate immune response. Neutrophils show …
organisms and have a major role in the innate immune response. Neutrophils show …
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality
As extracellular vesicles that play an active role in intercellular communication by
transferring cellular materials to recipient cells, exosomes offer great potential as a natural …
transferring cellular materials to recipient cells, exosomes offer great potential as a natural …
Endothelial thrombomodulin downregulation caused by hypoxia contributes to severe infiltration and coagulopathy in COVID-19 patient lungs
Background Thromboembolism is a life-threatening manifestation of coronavirus disease
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells …
Validation of the Caprini venous thromboembolism risk assessment model in critically ill surgical patients
Importance Appropriate risk stratification for venous thromboembolism (VTE) is essential to
providing appropriate thromboprophylaxis and avoiding morbidity and mortality. Objective …
providing appropriate thromboprophylaxis and avoiding morbidity and mortality. Objective …
Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study
Purpose There is limited knowledge on how the source of infection impacts the host
response to sepsis. We aimed to compare the host response in sepsis patients with a single …
response to sepsis. We aimed to compare the host response in sepsis patients with a single …
Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study
LR Schouten, AH van Kaam, F Kohse, F Veltkamp… - Annals of intensive …, 2019 - Springer
Background Results from preclinical studies suggest that age-dependent differences in host
defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed …
defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed …
Neonatal sepsis: need for consensus definition, collaboration and core outcomes
CONCLUSIONS The recent introduction of Sepsis-3 for adults has triggered plans to
translate this to children and newborn infants and involvement in the Surviving Sepsis …
translate this to children and newborn infants and involvement in the Surviving Sepsis …
Alterations in intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in human endothelial cells
Abstract Alterations of Endothelial cells (ECs) play a critical role in different pathogenesis of
many serious human diseases, and dysfunction of the vascular endothelium is an indicator …
many serious human diseases, and dysfunction of the vascular endothelium is an indicator …