Determinants of enhancer and promoter activities of regulatory elements
R Andersson, A Sandelin - Nature Reviews Genetics, 2020 - nature.com
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
[HTML][HTML] Next generation sequencing technology: advances and applications
HPJ Buermans, JT Den Dunnen - … Acta (BBA)-Molecular Basis of Disease, 2014 - Elsevier
Impressive progress has been made in the field of Next Generation Sequencing (NGS).
Through advancements in the fields of molecular biology and technical engineering …
Through advancements in the fields of molecular biology and technical engineering …
Cancer transcriptome profiling at the juncture of clinical translation
M Cieślik, AM Chinnaiyan - Nature Reviews Genetics, 2018 - nature.com
Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …
RNA sequencing: advances, challenges and opportunities
F Ozsolak, PM Milos - Nature reviews genetics, 2011 - nature.com
In the few years since its initial application, massively parallel cDNA sequencing, or RNA-
seq, has allowed many advances in the characterization and quantification of …
seq, has allowed many advances in the characterization and quantification of …
Conserved role of intragenic DNA methylation in regulating alternative promoters
AK Maunakea, RP Nagarajan, M Bilenky, TJ Ballinger… - Nature, 2010 - nature.com
Although it is known that the methylation of DNA in 5′ promoters suppresses gene
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
expression, the role of DNA methylation in gene bodies is unclear,,,,. In mammals, tissue …
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
E de Klerk, P AC't Hoen - Trends in Genetics, 2015 - cell.com
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
Metazoan promoters: emerging characteristics and insights into transcriptional regulation
Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …
elements, sequence motifs, the choice of transcription start sites and other features. Several …
[HTML][HTML] On the presence and role of human gene-body DNA methylation
DNA methylation of promoter sequences is a repressive epigenetic mark that down-
regulates gene expression. However, DNA methylation is more prevalent within gene …
regulates gene expression. However, DNA methylation is more prevalent within gene …
A user's guide to the encyclopedia of DNA elements (ENCODE)
ENCODE Project Consortium - PLoS biology, 2011 - journals.plos.org
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the
scientific and medical communities to interpret the human genome sequence and apply it to …
scientific and medical communities to interpret the human genome sequence and apply it to …
A user's guide to the encyclopedia of DNA elements (ENCODE)
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the
scientific and medical communities to interpret the human genome sequence and apply it to …
scientific and medical communities to interpret the human genome sequence and apply it to …