The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …

The coordinated regulation between cellular glucose uptake and endogenous glucose
production is indispensable for the maintenance of constant blood glucose concentrations …

Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective
treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics …

Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …

Adipocytes can increase in volume up to a thousand-fold, storing excess calories as
triacylglycerol in large lipid droplets. The dramatic morphological changes required of …

Авторами проведён анализ многочисленных научных исследований, касающихся
проблемы сахарного диабета II типа, масштабы распространения которого вызывают …

Aim We compared the efficacy of n3-polyunsaturated fatty acids (n3-PUFAs) and metformin
in halting the progression of non-alcoholic fatty liver disease (NAFLD) developed in the …

Cardiometabolic disorders are associated with a substantial loss in quality of life and pose a
large burden on healthcare systems worldwide. Overactivation of the sympathetic nervous …

Background Insulin resistance precedes metabolic syndrome which increases the risk of
type 2 diabetes and cardiovascular disease. However, there is a lack of safe and long …