Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease
pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases …

Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

The translocator protein (TSPO) is an outer mitochondrial membrane protein that is widely
used as a biomarker of neuroinflammation, being markedly upregulated in activated …

Following the impressive progress in the treatment of relapsing–remitting multiple sclerosis
(MS), the major challenge ahead is the development of treatments to prevent or delay the …

Neuroinflammation, which involves microglial activation, is thought to play a key role in the
development and progression of neurodegenerative diseases and other brain pathologies …

Microglia mediated inflammation contributes to intracerebral hemorrhage (ICH) induced
secondary injury. Activated microglia has dual functions as pro-inflammatory (M1) and anti …

Neurosteroids are steroid hormones synthesised de novo in the brain and peripheral
nervous tissues. In contrast to adrenal steroid hormones that act on intracellular nuclear …