Prospective evaluation of the prevalence of non-alcoholic fatty liver disease and steatohepatitis in a large middle-aged US cohort

SA Harrison, S Gawrieh, K Roberts, CJ Lisanti… - Journal of …, 2021 - Elsevier
Background & Aims Large prospective studies to establish the prevalence of non-alcoholic
fatty liver disease (NAFLD) and steatohepatitis (NASH), are lacking. We prospectively …

[PDF][PDF] Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n‐3 and n‐6 polyunsaturated fatty acids

BM Arendt, EM Comelli, DWL Ma, W Lou… - …, 2015 - Wiley Online Library
In nonalcoholic fatty liver disease, hepatic gene expression and fatty acid (FA) composition
have been reported independently, but a comprehensive gene expression profiling in …

High prevalence of nonalcoholic fatty liver disease in adolescents undergoing bariatric surgery

SA Xanthakos, TM Jenkins, DE Kleiner, TW Boyce… - Gastroenterology, 2015 - Elsevier
Background & Aims Little is known about the prevalence of nonalcoholic fatty liver disease
(NAFLD) among severely obese adolescents or factors that determine its development. We …

Antibody-directed glucocorticoid targeting to CD163 in M2-type macrophages attenuates fructose-induced liver inflammatory changes

P Svendsen, JH Graversen, A Etzerodt, H Hager… - … Therapy Methods & …, 2017 - cell.com
Increased consumption of high-caloric carbohydrates contributes substantially to endemic
non-alcoholic fatty liver disease in humans, covering a histological spectrum from fatty liver …

[PDF][PDF] Regulatory MiR‐148a‐ACVR1/BMP circuit defines a cancer stem cell‐like aggressive subtype of hepatocellular carcinoma

L Li, Y Liu, Y Guo, B Liu, Y Zhao, P Li, F Song… - …, 2015 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the
third most common cancer in Asia. HCC has heterogeneous etiologic and molecular profiles …

Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study

MC Morrison, R Kleemann, A Van Koppen… - Frontiers in …, 2018 - frontiersin.org
Introduction: It is generally accepted that metabolic inflammation in the liver is an important
driver of disease progression in NASH and associated matrix remodeling/fibrosis. However …

Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease?–A mechanistic hypothesis

IC de Medeiros, JG de Lima - Medical Hypotheses, 2015 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) are so
similar that only a detailed history of alcohol intake can distinguish one from the other …

Pentoxifylline for the treatment of nonalcoholic fatty liver disease: a meta-analysis of randomized double-blind, placebo-controlled studies

T Zeng, CL Zhang, XL Zhao, KQ Xie - European Journal of …, 2014 - journals.lww.com
Aims Pentoxifylline has been used to treat nonalcoholic fatty liver diseases (NAFLDs) due to
its anti-tumor necrosis factor-α effects. We conducted a meta-analysis of randomized, double …

Cancer-related gene expression is associated with disease severity and modifiable lifestyle factors in non-alcoholic fatty liver disease

BM Arendt, A Teterina, P Pettinelli, EM Comelli… - Nutrition, 2019 - Elsevier
Objective The aim of this study was to determine whether hepatic gene expression related to
hepatocellular carcinoma (HCC) is associated with disease severity and modifiable lifestyle …

Identification of core gene networks and hub genes associated with progression of non‐alcoholic fatty liver disease by RNA sequencing

K Hotta, M Kikuchi, T Kitamoto, A Kitamoto… - Hepatology …, 2017 - Wiley Online Library
Aim Non‐alcoholic fatty liver disease (NAFLD) progresses because of the interaction
between numerous genes. Thus, we carried out a weighted gene coexpression network …