Chemotherapy combined with or without targeted therapy is the fundamental treatment for
metastatic colorectal cancer (mCRC). Due to the adverse effects of chemotherapeutic drugs …

Although immune checkpoint inhibitors (ICIs) that target programmed cell death protein-
1/programmed cell death ligand-1 axis have significantly shifted the treatment paradigm in …

Immune checkpoint blockade (ICB) can produce durable responses against cancer. We and
others have found that a subset of patients experiences paradoxical rapid cancer …

In the past 10 years, a deeper understanding of the immune landscape of cancers, including
immune evasion processes, has allowed the development of a new class of agents. The …

Immunotherapy has achieved unprecedented clinical efficacy in patients with various types
of advanced tumors; however, some patients experience delayed tumor shrinkage following …

Importance Hyperprogressive disease (HPD) is a recognized pattern of rapid tumor
progression during immune checkpoint inhibitor (ICI) treatment. Definitions of HPD have not …

Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different
types of tumors, leading to improvement in survival, even in patients with advanced cancers …

Abstract Background Mutations in STK11 (STK11 Mut) and, frequently co-occurring, KEAP1
mutations (KEAP1 Mut) are associated with poor survival in metastatic Non-small Cell Lung …

Background: Beyond programmed death ligand 1 (PD-L1), no other biomarkers for
immunotherapy are used in daily practice. We previously created EPSILoN (Eastern …

Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionised treatment of
advanced non-small cell lung cancer (aNSCLC), but a proportion of patients had no clinical …