Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Fluorescence microscopy provides an efficient and unique approach to study fixed and
living cells because of its versatility, specificity, and high sensitivity. Fluorescence …

C-type lectin receptors (CLRs) play critical roles as pattern-recognition receptors (PRRs) for
sensing Candida albicans infection, which can be life-threatening for immunocompromised …

Complex protein networks are involved in nearly all cellular processes. To uncover these
vast networks of protein interactions, various high-throughput screening technologies have …

Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ
orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

Spinal muscular atrophy (SMA) results from reduced levels of the survival of motor neuron
(SMN) protein, which has a well characterized function in spliceosomal small nuclear …

Many proteins can be split into fragments that spontaneously reassemble, without covalent
linkage, into a functional protein. For split green fluorescent proteins (GFPs), fragment …

Covalent modification of proteins with ubiquitin is essential for the majority of biological
processes in mammalian cells. Numerous proteins are conjugated with single or multiple …