[HTML][HTML] Biological and clinical aspects of HPV-related cancers

KA Szymonowicz, J Chen - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Cancer-related diseases represent the second overall cause of death worldwide. Human
papilloma virus (HPV) is an infectious agent which is mainly sexually transmitted and may …

The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

JA Scarth, MR Patterson… - Journal of General …, 2021 - microbiologyresearch.org
Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Human papillomavirus molecular biology and disease association

J Doorbar, N Egawa, H Griffin… - Reviews in medical …, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) have evolved over millions of years to propagate
themselves in a range of different animal species including humans. Viruses that have co …

[HTML][HTML] Opportunities and challenges for human papillomavirus vaccination in cancer

R Roden, PL Stern - Nature Reviews Cancer, 2018 - nature.com
The discovery of genotype 16 as the prototype oncogenic human papillomavirus (HPV)
initiated a quarter century of laboratory and epidemiological studies that demonstrated their …

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …

The role of integration in oncogenic progression of HPV-associated cancers

AA McBride, A Warburton - PLoS pathogens, 2017 - journals.plos.org
Persistent infection with a subset of “high oncogenic risk” human papillomaviruses (HPVs)
can promote the development of cancer. In these cancers, the extrachromosomal viral …

The biology and life-cycle of human papillomaviruses

J Doorbar, W Quint, L Banks, IG Bravo, M Stoler… - Vaccine, 2012 - Elsevier
Human papillomaviruses (HPVs) comprise a diverse group, and have different epithelial
tropisms and life-cycle strategies. Many HPVs are classified as low-risk, as they are only …

Human papillomavirus oncoproteins: pathways to transformation

CA Moody, LA Laimins - Nature reviews cancer, 2010 - nature.com
An association between human papillomavirus (HPV) infection and the development of
cervical cancer was initially reported over 30 years ago, and today there is overwhelming …

The causal relation between human papillomavirus and cervical cancer

FX Bosch, A Lorincz, N Muñoz, C Meijer… - Journal of clinical …, 2002 - jcp.bmj.com
The causal role of human papillomavirus infections in cervical cancer has been documented
beyond reasonable doubt. The association is present in virtually all cervical cancer cases …

High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis

NSL Yeo-Teh, Y Ito, S Jha - International journal of molecular sciences, 2018 - mdpi.com
Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …