Renoprotective effects of luteolin: Therapeutic potential for COVID-19-associated acute kidney injuries

LRL Diniz, HA Elshabrawy, MTS Souza, ABS Duarte… - Biomolecules, 2022 - mdpi.com
Acute kidney injury (AKI) has been increasingly reported in critically-ill COVID-19 patients.
Moreover, there was significant positive correlation between COVID-19 deaths and renal …

Pharmacological agents for the prevention of colistin-induced nephrotoxicity

M Mirjalili, E Mirzaei, A Vazin - European Journal of Medical Research, 2022 - Springer
Background Colistin is a polymyxin antibiotic which has been used for treatment of Gram-
negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has …

Alpha-lipoic acid alleviates colistin nephrotoxicity in rats

MA Oktan, C Heybeli, C Ural, A Kocak… - Human & …, 2021 - journals.sagepub.com
Colistin methanesulfonate (CMS), a clinical form of colistin, is widely used as a last-line
treatment for multidrug-resistant (MDR) gram-negative bacterial infections in critically ill …

Curcumin supplementation alleviates polymyxin E-induced nephrotoxicity

A Vazin, R Heidari, Z Khodami - Journal of Experimental …, 2020 - Taylor & Francis
Background The last-line agent for gram-negative bacteria that have developed resistance
towards commonly used antibiotics is polymyxin E (PolyE). The renal toxicity attributed to …

Delineation of the molecular mechanisms underlying Colistin-mediated toxicity using metabolomic and transcriptomic analyses

NP Long, JH Oh, SM Park, NTH Yen, NK Phat… - Toxicology and Applied …, 2022 - Elsevier
The mechanisms underlying colistin-induced toxicity are not fully understood. This study
used untargeted metabolomics and transcriptomics to elucidate the molecular processes …

Utilizing liposomal encapsulation approach to address nephrotoxic challenges of colistimethate sodium through a preclinical study

R Mektrirat, N Paengjun… - Frontiers in …, 2023 - frontiersin.org
The use of Colistin, a last-resort antimicrobial drug, carries the risk of acute kidney injury.
The objective of the study was to assess the effectiveness of colistin-encapsulated …

Dexmedetomidine may reduce the risk of acute kidney injury development in critically ill patients during colistin therapy

M Kucuk, C Heybeli, MC Ozturk, B Ergun… - Journal of Infection and …, 2023 - Elsevier
Introduction Colistin is considered as a last resort therapy for multidrug-resistant gram-
negative organisms. It is widely used despite the significant risk of nephrotoxicity …

Effectiveness of the drug Kolidev 8M (powder for oral use) for the treatment of bacterial infections in decorative birds and European fallow deer

RM Sachuk, BV Gutyj, TA Velesyk… - Theoretical and …, 2022 - bulletin-biosafety.com
Clinical tests of the commercial veterinary drug Kolidev 8M (powder for oral use)
manufactured by «DEVIE» LLC (Ukraine) were conducted for the treatment of bacterial …

Genome-wide gene expression analysis reveals molecular insights into the drug-induced toxicity of nephrotoxic agents

NTH Yen, SM Park, VTA Thu, NK Phat, YS Cho, S Yoon… - Life Sciences, 2022 - Elsevier
Drug-induced nephrotoxicity is frequently reported. However, the mechanisms underlying
nephrotoxic medications and their overlapping molecular events, which might have …

[HTML][HTML] Can magnesium sulfate prophylaxis reduce colistin nephrotoxicity?

YC Yavuz, N Cetin, E Menevşe, A Cizmecioglu, E Celik… - nefrologia, 2021 - Elsevier
The study aimed to investigate the role of magnesium sulfate prophylaxis in nephrotoxicity
caused by colistin. Thirty Wistar Albino rats were divided into four groups: control, colistin …