Therapeutic drug monitoring (TDM) has emerged as a strategy for treatment optimization in
inflammatory bowel diseases to maximize benefit and to reach more stringent, objective end …

The disorders collectively known as inflammatory bowel disease (IBD) include Crohn's
disease (CD) and ulcerative colitis (UC). CD, initially credited as having been described in …

Background: The contemporary management of ambulatory ulcerative colitis (UC) continues
to be challenging with∼ 20% of children needing a colectomy within childhood years. We …

Guidelines for clinical practice are intended to indicate preferred approaches to medical
problems as established by scientifically valid research. Double-blind placebo-controlled …

Background & Aims: 6-Thioguanine nucleotide (6-TGN) levels have been proposed to
correlate with inflammatory bowel disease (IBD) activity among patients treated with …

AIM Probably, the most important and potentially lethal adverse event of azathioprine (AZA)
and mercaptopurine (MP) is myelosuppression. Our aim was to conduct a review of AZA/MP …

6-Mercaptopurine and its prodrug azathioprine remain the mainstay of immunomodulator
therapy for the maintenance of a steroid-free remission in patients with IBD. Recent …

Steps preceding introduction of the analytical sample into individual separation equipment
and/or mass-spectrometry (MS) detectors for targeted or untargeted metabolomics studies …

Aliment Pharmacol Ther 2012; 35: 15–36 Summary Background Thiopurines represent an
effective and widely prescribed therapy in inflammatory bowel disease (IBD). Concerns …

Background In the past 10–20 years, knowledge of both thiopurine pharmacology and‐
pharmacogenetics has been extended dramatically and used to develop new strategies to …