The evolving view of thermogenic adipocytes—ontogeny, niche and function
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …
reached pandemic levels. Central to the development of these metabolic disorders is …
Brown adipose tissue as a secretory organ
Brown adipose tissue (BAT) is the main site of adaptive thermogenesis and experimental
studies have associated BAT activity with protection against obesity and metabolic diseases …
studies have associated BAT activity with protection against obesity and metabolic diseases …
Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations
Y Ni, L Qian, SL Siliceo, X Long, E Nychas, Y Liu… - Cell Metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic dysfunction
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
for which effective interventions are lacking. To investigate the effects of resistant starch (RS) …
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-
associated metabolic complications. However, the molecular links between lipid-overloaded …
associated metabolic complications. However, the molecular links between lipid-overloaded …
Targeting adipose tissue in the treatment of obesity-associated diabetes
CM Kusminski, PE Bickel, PE Scherer - Nature reviews Drug discovery, 2016 - nature.com
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
[HTML][HTML] Gut microbiome fermentation determines the efficacy of exercise for diabetes prevention
Exercise is an effective strategy for diabetes management but is limited by the phenomenon
of exercise resistance (ie, the lack of or the adverse response to exercise on metabolic …
of exercise resistance (ie, the lack of or the adverse response to exercise on metabolic …
SGLT2 inhibition by empagliflozin promotes fat utilization and browning and attenuates inflammation and insulin resistance by polarizing M2 macrophages in diet …
Abstract Sodium-glucose cotransporter (SGLT) 2 inhibitors increase urinary glucose
excretion (UGE), leading to blood glucose reductions and weight loss. However, the impacts …
excretion (UGE), leading to blood glucose reductions and weight loss. However, the impacts …
Regulation of metabolism by the innate immune system
DE Lackey, JM Olefsky - Nature Reviews Endocrinology, 2016 - nature.com
Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …
Macrophage polarization and meta-inflammation
Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …
Adipose tissue macrophages: going off track during obesity
L Boutens, R Stienstra - Diabetologia, 2016 - Springer
Inflammation originating from the adipose tissue is considered to be one of the main driving
forces for the development of insulin resistance and type 2 diabetes in obese individuals …
forces for the development of insulin resistance and type 2 diabetes in obese individuals …