Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Natural products have a broad diversity of multidimensional chemical formations, which play
an important role, and indicate the crucial nature as a golden source for gaining herbal drug …

One of the classic hallmarks of cancer is the imbalance between elevated cell proliferation
and reduced cell death. Ceramide, a bioactive sphingolipid that can regulate this balance …

Recently, we reported that N-acetyltransferase 10 (NAT10) regulates fatty acid metabolism
through ac4C-dependent RNA modification of key genes in cancer cells. During this work …

Doxorubicin (Dox) induces senescence in numerous cancer cell types, but these senescent
cancer cells relapse again if they are not eliminated. On this principle, we investigated the …

Combining chemotherapeutic agents with bioactive natural products is an attractive cancer
treatment modality to reduce the dose and side effects of chemotherapy. Combination …

Cancer causes a considerable amount of mortality in the world, while arthritis is an
immunological dysregulation with multifactorial pathogenesis including genetic and …

Cancer can develop due to abnormal cell proliferation in any body's cells, so there are over
a hundred different types of cancer, each with its distinct behavior and response to …

Ceramides, the core of the sphingolipid metabolism, draw wide attention as tumor
suppressor, and act directly on mitochondria to trigger apoptotic cell death. Ceramide-based …