The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …

With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for
organ engineering were generated from numerous tissues, including the heart, lung, liver …

Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the
third leading cause of death worldwide. COPD is characterized by chronic airway …

Pulmonary acute and chronic diseases, such as chronic obstructive pulmonary disease,
pulmonary fibrosis and pulmonary hypertension, are considered to be major health issues …

The complexity and rapid clearance mechanisms of lung tissue make it difficult to develop
effective treatments for many chronic pathologies. We are investigating lung derived …

Building a good lung, capable of efficient gas exchange between air and blood, poses a
number of conflicting problems for physiology and cell biology. One of these is the complex …

Acellular whole human lung scaffolds represent a unique opportunity for ex vivo tissue
engineering. However, it remains unclear whether lungs from individuals with chronic lung …

Using an innovative, tissue‐independent approach to decellularized tissue processing and
biomaterial fabrication, the development of a series of “tissue papers” derived from native …

Naturally-derived biomaterials have been used for decades in multiple regenerative
medicine applications. From the simplest cell microcarriers made of collagen or alginate, to …