Restless legs syndrome
M Manconi, D Garcia-Borreguero… - Nature reviews Disease …, 2021 - nature.com
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …
Brain mechanisms of insomnia: new perspectives on causes and consequences
EJW Van Someren - Physiological reviews, 2021 - journals.physiology.org
While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …
of underlying neurobiological mechanisms has been limited. The present review addresses …
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
JM Lane, J Liang, I Vlasac, SG Anderson… - Nature …, 2017 - nature.com
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …
[HTML][HTML] Restless legs syndrome: contemporary diagnosis and treatment
TR Gossard, LM Trotti, A Videnovic, EK St Louis - Neurotherapeutics, 2021 - Elsevier
Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs
while at rest, relief upon movement or getting up to walk, and worsened symptom severity at …
while at rest, relief upon movement or getting up to walk, and worsened symptom severity at …
Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits
AR Hammerschlag, S Stringer, CA De Leeuw… - Nature …, 2017 - nature.com
Persistent insomnia is among the most frequent complaints in general practice. To identify
genetic factors for insomnia complaints, we performed a genome-wide association study …
genetic factors for insomnia complaints, we performed a genome-wide association study …
Restless legs syndrome associated with major diseases: a systematic review and new concept
Recent publications on both the genetics and environmental factors of restless legs
syndrome (RLS) defined as a clinical disorder suggest that overlapping genetic risk factors …
syndrome (RLS) defined as a clinical disorder suggest that overlapping genetic risk factors …
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
Our sleep timing preference, or chronotype, is a manifestation of our internal biological
clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical …
clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical …
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
B Schormair, C Zhao, S Bell, E Tilch… - The Lancet …, 2017 - thelancet.com
Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …
potentially severe mental and physical health consequences. Clearer understanding of the …
Genome-wide physical activity interactions in adiposity―A meta-analysis of 200,452 adults
M Graff, RA Scott, AE Justice, KL Young… - PLoS …, 2017 - journals.plos.org
Physical activity (PA) may modify the genetic effects that give rise to increased risk of
obesity. To identify adiposity loci whose effects are modified by PA, we performed genome …
obesity. To identify adiposity loci whose effects are modified by PA, we performed genome …