Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

The global pharmaceutical market has recently shifted its focus from small molecule drugs to
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …

Increasing attention has been paid to developability assessment with the understanding that
thorough evaluation of monoclonal antibody lead candidates at an early stage can avoid …

This study developed a sensitive and easy method to directly analyze N ε-(carboxymethyl)
lysine (CML) by ultra-performance liquid chromatography tandem mass spectrometry (UPLC …

Context Demonstrating the ability to mount a neutralizing antibody response to SARS-CoV-2
in the presence of diabetes is crucial to understand COVID-19 pathogenesis, reinfection …

Capillary isoelectric focusing with whole-column imaging detection (icIEF) technology is now
the mainstream technology to perform analytical isoelectric focusing analysis in …

Charged heterogeneity of monoclonal antibody (mAb) products is regarded as a critical
quality attribute (CQA) depending on its impact on the safety and efficacy profile of the …

Purpose: Therapeutic proteins are sensitive to photo-degradation by UV A and visible light.
As none of the essential amino acids exhibits significant absorption in the UV A and visible …

Rapid, direct identification and quantitation of protein charge variants, and assessment of
critical quality attributes with high sensitivity are important drivers required to accelerate the …

The importance of IgG glycosylation has been known for many years not only by scientists in
glycobiology but also by human pathogens that have evolved specific enzymes to modify …