The role of iron in DNA and genomic instability in cancer, a target for iron chelators that can induce ROS
A Carter, S Racey, S Veuger - Applied Sciences, 2022 - mdpi.com
Iron is a key metal involved in several biological processes such as DNA replication and
repair, cellular proliferation and cell cycle regulation. Excess volumes of labile iron are toxic …
repair, cellular proliferation and cell cycle regulation. Excess volumes of labile iron are toxic …
[HTML][HTML] Biomechanical characteristics of silver enriched diamond-like carbon coatings for medical applications
Silver enriched diamond-like carbon (Ag/DLC) coatings are gaining a reputation for medical
applications as Ag doping improves the intrinsic biocompatibility and antimicrobial features …
applications as Ag doping improves the intrinsic biocompatibility and antimicrobial features …
[HTML][HTML] Thermal activation of Ti (1-x) Au (x) thin films with enhanced hardness and biocompatibility
CC Lukose, I Anestopoulos, T Mantso, L Bowen… - Bioactive Materials, 2022 - Elsevier
The lifetime of orthopaedic implants can be extended by coating the softer Ti 6 Al 4 V alloy
with harder biocompatible thin films. In this work, thin films of Ti (1-x) Au (x) are grown on Ti 6 …
with harder biocompatible thin films. In this work, thin films of Ti (1-x) Au (x) are grown on Ti 6 …
[HTML][HTML] Saponin and Phenolic Composition and Assessment of Biological Activities of Saponaria officinalis L. Root Extracts
D Charalambous, M Christoforou, K Christou… - Plants, 2024 - mdpi.com
The purpose of this study was to identify the saponin and phenolic components in root
extracts of Saponaria officinalis, a widespread species, found in Cyprus. A total of six major …
extracts of Saponaria officinalis, a widespread species, found in Cyprus. A total of six major …
Novel iron chelator SK4 demonstrates cytotoxicity in a range of tumour derived cell lines
G Abdelaal, A Carter, MI Panayiotides… - Frontiers in Molecular …, 2022 - frontiersin.org
Iron is an essential micronutrient due to its involvement in many cellular processes including
DNA replication and OXPHOS. Tumors overexpress iron metabolism linked proteins which …
DNA replication and OXPHOS. Tumors overexpress iron metabolism linked proteins which …
Novel Iron Chelator SK4 Drives Cytotoxicity through Inhibiting Mitochondrial Metabolism in Ovarian and Triple Negative Breast Cancer Cell Lines
G Abdelaal, A Carter, W Cheung, M Panayiotidis… - Biomedicines, 2023 - mdpi.com
Anti-cancer therapy by iron chelation has been shown to inhibit many cellular processes
including DNA replication, mitochondrial metabolism and oncogenic signalling pathways …
including DNA replication, mitochondrial metabolism and oncogenic signalling pathways …