Chondrocytes communicate with each other mainly via diffusible signals rather than direct
cell‐to‐cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is …

The periosteum, with its outer fibrous and inner cambium layer, lies in a dynamic
environment with a niche of pluripotent stem cells for their reparative needs. The inner …

Regenerated silk fibroin (RSF) of Bombyx mori silk fiber is a promising natural material for
bone defect repair. However, a lack of specific integrin and growth factor for osteoinduction …

Despite the promise of hydrogel-based stem cell therapies in orthopedics, a significant need
still exists for the development of injectable microenvironments capable of utilizing the …

TET2 is a methylcytosine dioxygenase that regulates cytosine hydroxymethylation. Although
there are extensive data implicating a pivotal role of TET2 in hematopoietic stem/progenitor …

During in vitro culture, bereft of their optimal tissue context, tenocytes lose their phenotype
and function. Considering that tenocytes in their native tissue milieu are exposed …

Silk fibroin is regarded as a promising biomaterial in various areas, including bone tissue
regeneration. Herein, Laponite®(LAP), which can promote osteogenic differentiation, was …

Current clinical strategies for restoring cartilage defects do not adequately consider taking
the necessary steps to prevent the formation of hypertrophic tissue at injury sites …

Background Tumours are not only composed of malignant cells but also consist of a stromal
micro-environment, which has been shown to influence cancer cell behaviour. Because the …

Background A developmental transition from aquatic to terrestrial existence is one of the
most important events in the evolution of terrestrial vertebrates. Amphibian metamorphosis is …