Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Context Considerable controversy exists regarding the association of omega-3
polyunsaturated fatty acids (PUFAs) and major cardiovascular end points. Objective To …

Objective To investigate the effects on cardiovascular outcomes of drug interventions that
increase high density lipoprotein levels. Design Meta-analysis. Studies reviewed …

Objective The development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology …

Men and women exhibit significant differences in obesity, cardiovascular disease, and
diabetes. To provide better diagnosis and treatment for both sexes, it is important to identify …

Background Sex differences in obesity and related diseases are well established. Gonadal
hormones are a major determinant of these sex differences. However, sex differences in …

METHODS This CPG was developed in accordance with the AACE Protocol for
Standardized Production of Clinical Practice Guidelines—2010 Update (

Polygenic risk scores (PRS) are commonly used to quantify the inherited susceptibility for a
trait, yet they fail to account for non-linear and interaction effects between single nucleotide …

Statins inhibit the critical step of cholesterol synthesis in which 3-hydroxy-3-methylglutaryl
coenzyme A (HMGC) is transformed to mevalonate by the enzyme HMGC reductase. By …

An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic
lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate …