Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

JL Silverman, A Thurm, SB Ethridge… - Genes, brain and …, 2022 - Wiley Online Library
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and
intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence‐based …

Emerging connections between cerebellar development, behaviour and complex brain disorders

A Sathyanesan, J Zhou, J Scafidi, DH Heck… - Nature Reviews …, 2019 - nature.com
The human cerebellum has a protracted developmental timeline compared with the
neocortex, expanding the window of vulnerability to neurological disorders. As the …

The neuroanatomy of autism–a developmental perspective

APA Donovan, MA Basson - Journal of anatomy, 2017 - Wiley Online Library
Abstract Autism Spectrum Disorders (ASD s) are a heterogeneous group of
neurodevelopmental disorders that are diagnosed solely on the basis of behaviour. A large …

Noradrenergic modulation of cognition in health and disease

O Borodovitsyna, M Flamini, D Chandler - Neural plasticity, 2017 - Wiley Online Library
Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic
transmission in the central nervous system through its actions at a number of pre‐and …

Serotonin neuron development: shaping molecular and structural identities

E Deneris, P Gaspar - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
The continuing fascination with serotonin (5‐hydroxytryptamine, 5‐HT) as a nervous system
chemical messenger began with its discovery in the brains of mammals in 1953. Among the …

[HTML][HTML] Implication of hippocampal neurogenesis in autism spectrum disorder: Pathogenesis and therapeutic implications

C Liu, J Liu, H Gong, T Liu, X Li… - Current …, 2023 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is a cluster of heterogeneous neurodevelopmental
conditions with atypical social communication and repetitive sensory-motor behaviors. The …

Norepinephrine, neurodevelopment and behavior

E Saboory, M Ghasemi, N Mehranfard - Neurochemistry international, 2020 - Elsevier
Neurotransmitters play critical roles in the developing nervous system. Among the
neurotransmitters, norepinephrine (NE) is in particular postulated to be an important …

Aberrant somatosensory processing and connectivity in mice lacking Engrailed-2

G Chelini, V Zerbi, L Cimino, A Grigoli… - Journal of …, 2019 - Soc Neuroscience
Overreactivity and defensive behaviors in response to tactile stimuli are common symptoms
in autism spectrum disorder (ASD) patients. Similarly, somatosensory hypersensitivity has …

Deltamethrin exposure inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice

MM Hossain, A Belkadi, S Al-Haddad… - Toxicological …, 2020 - academic.oup.com
Deficits in learning and memory are often associated with disruption of hippocampal
neurogenesis, which is regulated by numerous processes, including precursor cell …

Knowledge-guided bioinformatics model for identifying autism spectrum disorder diagnostic MicroRNA biomarkers

L Shen, Y Lin, Z Sun, X Yuan, L Chen, B Shen - Scientific reports, 2016 - nature.com
Autism spectrum disorder (ASD) is a severe neurodevelopmental disease with a high
incidence and effective biomarkers are urgently needed for its diagnosis. A few previous …