Sensory encoding and memory in the mushroom body: signals, noise, and variability

M Parnas, JE Manoim, AC Lin - Learning & Memory, 2024 - learnmem.cshlp.org
To survive in changing environments, animals need to learn to associate specific sensory
stimuli with positive or negative valence. How do they form stimulus-specific memories to …

Increased understanding of complex neuronal circuits in the cerebellar cortex

S Jun, H Park, M Kim, S Kang, T Kim, D Kim… - Frontiers in Cellular …, 2024 - frontiersin.org
The prevailing belief has been that the fundamental structures of cerebellar neuronal
circuits, consisting of a few major neuron types, are simple and well understood. Given that …

DART. 2: bidirectional synaptic pharmacology with thousandfold cellular specificity

BC Shields, H Yan, SSX Lim, SCV Burwell… - Nature …, 2024 - nature.com
Precision pharmacology aims to manipulate specific cellular interactions within complex
tissues. In this pursuit, we introduce DART. 2 (drug acutely restricted by tethering), a second …

GlyT2-positive interneurons regulate timing and variability of information transfer in a cerebellar-behavioural loop

ER Palacios, C Houghton, P Chadderton - Journal of Neuroscience, 2024 - jneurosci.org
GlyT2-positive interneurons, Golgi and Lugaro cells, reside in the input layer of the
cerebellar cortex in a key position to influence information processing. Here, we examine the …

Balance performance in aged mice is dependent on unipolar brush cells

G Kizeev, I Witteveen, T Balmer - The Cerebellum, 2025 - Springer
The vestibular processing regions of the cerebellum integrate vestibular information with
other sensory modalities and motor signals to regulate balance, gaze stability, and spatial …

Understanding Cerebellar Input Stage through Computational and Plasticity Rules

E Pali, E D'Angelo, F Prestori - Biology, 2024 - mdpi.com
Simple Summary One of the main theories regarding brain functioning is that plasticity
modifies the effectiveness of synaptic transmission to control the signal transfer function. It …

Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination

J Kwon, S Kim, J Woo, E De Schutter, S Hong, CJ Lee - bioRxiv, 2024 - biorxiv.org
Tonic inhibition in cerebellar granule cells (GC) is crucial in information coding fidelity for
motor coordination. It emerges in activity-dependent and-independent manners, and their …