In recent years, the influence of the IGF system and insulin on cancer growth has been
widely studied. Observational human studies have reported increased cancer mortality in …

Insulin is an important polypeptide hormone that regulates carbohydrate metabolism.
Abnormal levels of insulin are associated with diabetes mellitus that is characterized by …

OBJECTIVE Observational studies examining the association between long-acting insulin
analogs and cancer incidence have produced inconsistent results. We conducted a …

Aims/hypothesis There have been growing concerns regarding the long-term effects of
insulin glargine (A21Gly, B31Arg, B32Arg human insulin) on the risk of breast cancer …

Abstract Aims/hypothesis Using the Echantillon Généraliste de Bénéficiaires: random 1/97
permanent sample of the French national healthcare insurance system database (EGB), we …

Since its discovery and first clinical use in the 1920s, insulin therapy has revolutionized the
treatment and natural history of both type 1 and type 2 diabetes mellitus. This article …

Globally at 2014, it was estimated that there was 347 million people with diabetes in which
90 percent of them were diagnosed with type 2 diabetes mellitus (T2 DM). Although the …

Insulin replacement therapy is a widely adopted treatment for all patients with type 1
diabetes and some with type 2 diabetes. However, injection of insulin has suffered from …

Context: Retrospective, observational studies have reported an association between
diabetes treatment with insulin and a higher incidence of cancer. Objective: Overview the …

Hyperinsulinemia is a likely cause of the increased cancer incidence and mortality in
diabetic patients, but its role is difficult to define in vivo. Previous in vitro studies testing the …