Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Biological membranes (biomembranes) are one of the most complicated structures that
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …

The human islet amyloid polypeptide (hIAPP) or amylin, a neuroendocrine peptide hormone,
is known to misfold and form amyloidogenic aggregates that have been observed in the …

This Perspective highlights recent computational approaches to protein aggregation, from
coarse-grained models to atomistic simulations, using the islet amyloid polypeptide (IAPP) …

Lipids and proteins are the main components of cell membranes. It is becoming increasingly
clear that lipids, in addition to providing an environment for proteins to work in, are in many …

The islet amyloid polypeptide (IAPP), also known as amylin, is a hormone playing key
physiological roles. However, its aggregation and deposition in the pancreatic islets are …

The interactions between proteins and membranes play critical roles in signal transduction,
cell motility, and transport, and they are involved in many types of diseases. Molecular …

Amyloidogenic proteins are related to a variety of amyloid diseases, such as type 2 diabetes
(T2D), Alzheimer's disease (AD) and Parkinson's disease (PD). The amyloid proteins in …