The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

The intent of this review is to describe what is known and unknown about telomerase in
somatic cells of the human organism. First, we consider the telomerase enzyme. Human …

To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA
component (mTR) was deleted from the mouse germline. mTR−/− mice lacked detectable …

Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast
Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous …

Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal
human somatic cells but is reactivated during tumor progression. We report the cloning of a …

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome
termini in most eukaryotes. Telomerase RNA components have been identified from many …

The maintenance of chromosome termini, or telomeres, requires the action of the enzyme
telomerase, as conventional DNA poly-merases cannot fully replicate the ends of linear …

Telomerase, the enzyme that synthesizes telomeric DNA, is not expressed in most human
somatic cells but is activated with in vitro immortalization and during tumorigenesis, and …

Telomerase activation is thought to be a critical step in cellular immortalization and
carcinogenesis. Of the three major subunits comprising human telomerase, human …

Telomerase activity is present in most malignant tumors and provides a mechanism for the
unlimited potential for division of neoplastic cells. Although telomerase is known to be a …