Animal models are used to study many aspects of human disease and to test therapeutic
interventions. However, some very important features of human biology cannot be replicated …

Since the first human hepatocyte transplants (HTx) in 1992, clinical studies have clearly
established proof of principle for this therapy as a treatment for patients with acquired or …

Despite advances in stem cell research, cell transplantation therapy for liver failure is
impeded by a shortage of human primary hepatocytes (HPH), along with current …

Mesenchymal stem cells (MSCs) represent an attractive cell type for research and therapy
due to their ability to proliferate, differentiate, modulate immune reactions, and secrete …

Model animals naturally differ from humans in various respects and results from the former
are not directly translatable to the latter. One approach to address this issue is humanized …

Despite routine liver transplantation and supporting medical therapies, thousands of patients
currently wait for an organ and there is an unmet need for more refined and widely available …

Diseases of lipid metabolism are a major cause of human morbidity, but no animal model
entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse …

Perinatal tissues, such as placenta and umbilical cord contain a variety of somatic stem cell
types, spanning from the largely used hematopoietic stem and progenitor cells to the most …

Being an integral part of basic, translational and clinical research, the demand for primary
human hepatocytes (PHH) is continuously growing while the availability of tissue resection …

Advancement in both bioengineering and cell biology of the liver led to the establishment of
the first-generation humanized liver chimeric mouse (HLCM) model in 2001. The HLCM …