MicroRNA regulation by RNA-binding proteins and its implications for cancer
M Van Kouwenhove, M Kedde, R Agami - Nature Reviews Cancer, 2011 - nature.com
Non-protein-coding transcripts have been conserved throughout evolution, indicating that
crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found …
crucial functions exist for these RNAs. For example, microRNAs (miRNAs) have been found …
Post-transcriptional regulatory functions of mammalian pumilio proteins
AC Goldstrohm, TMT Hall, KM McKenney - TRENDS in Genetics, 2018 - cell.com
Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …
[PDF][PDF] Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins
Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse biological
processes. Here, we describe the initial functional analysis of a poorly characterized human …
processes. Here, we describe the initial functional analysis of a poorly characterized human …
A compendium of RNA-binding motifs for decoding gene regulation
RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …
been functionally characterized. Here we report a systematic analysis of the RNA motifs …
[PDF][PDF] Genome-wide functional screen of 3′ UTR variants uncovers causal variants for human disease and evolution
Summary 3′ untranslated region (3′ UTR) variants are strongly associated with human
traits and diseases, yet few have been causally identified. We developed the massively …
traits and diseases, yet few have been causally identified. We developed the massively …
A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility
M Kedde, M Van Kouwenhove, W Zwart… - Nature cell …, 2010 - nature.com
Key regulators of 3′ untranslated regions (3′ UTRs) are microRNAs and RNA-binding
proteins (RBPs),. The p27 tumour suppressor is highly expressed in quiescent cells, and its …
proteins (RBPs),. The p27 tumour suppressor is highly expressed in quiescent cells, and its …
[HTML][HTML] PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data
DL Corcoran, S Georgiev, N Mukherjee, E Gottwein… - Genome biology, 2011 - Springer
Crosslinking and immunoprecipitation (CLIP) protocols have made it possible to identify
transcriptome-wide RNA-protein interaction sites. In particular, PAR-CLIP utilizes a …
transcriptome-wide RNA-protein interaction sites. In particular, PAR-CLIP utilizes a …
Antiviral innate immunity and stress granule responses
K Onomoto, M Yoneyama, G Fung, H Kato, T Fujita - Trends in immunology, 2014 - cell.com
Viral infection triggers the activation of antiviral innate immune responses in mammalian
cells. Viral RNA in the cytoplasm activates signaling pathways that result in the production of …
cells. Viral RNA in the cytoplasm activates signaling pathways that result in the production of …
PUF proteins: repression, activation and mRNA localization
The eukaryotic family of RNA-binding proteins termed PUF (Pumilio and FBF) is known for
its roles in cell division, differentiation and development. The best-characterized function of …
its roles in cell division, differentiation and development. The best-characterized function of …
[HTML][HTML] Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system
A Galgano, M Forrer, L Jaskiewicz, A Kanitz… - PloS one, 2008 - journals.plos.org
Genome-wide identification of mRNAs regulated by RNA-binding proteins is crucial to
uncover post-transcriptional gene regulatory systems. The conserved PUF family RNA …
uncover post-transcriptional gene regulatory systems. The conserved PUF family RNA …