Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

The hyaline cartilage is the most abundant type of cartilage in the body. It is responsible for
the bone formation in the embryo (endochondral ossification) and in adults, it can be found …

Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …

Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints
such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and
what factors trigger the disease process remain unclear, although the mechanical …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …