Mild Alzheimer's disease is the leading cause of dementia, accounting for 50–70% of cases.
Alzheimer's disease is an irreversible neurodegenerative disease, which affects daily life …

Alzheimer's disease is one of the most common age-related neurodegenerative disorders.
The main theory of Alzheimer's disease progress is the amyloid-β cascade hypothesis …

We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of
PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …

Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk
factors throughout the life course. However, robust evidence for most of these risk factors is …

Mendelian-randomization (MR) studies using large-scale genome-wide association studies
(GWAS) have identified causal association between educational attainment and Alzheimer's …

Previous hypothesis-driven research has identified many risk factors linked to dementia.
However, the multiplicity and co-occurrence of risk factors have been underestimated. Here …

BackgroundPoor mental health has consistently been associated with substance use
(smoking, alcohol drinking, cannabis use, and consumption of caffeinated drinks). To …

The success of genome-wide association studies (GWAS) completed in the last 15 years
has reinforced a key fact: polygenic architecture makes a substantial contribution to variation …

The coconut tree (Cocos nucifera) which is also known as the “Tree of life” has its own
values in each part of the tree and coconut oil is more prestigious among them. At present …

Sleep and/or wake cycle alterations are common in neurodegenerative diseases (ND). Our
aim was to determine whether there is a causal relationship between sleep and/or wake …