Selecting the appropriate hurdles and endpoints for pentilludin, a novel antiaddiction pharmacotherapeutic targeting the receptor type protein tyrosine phosphatase D
GR Uhl - Frontiers in Psychiatry, 2023 - frontiersin.org
Substance use disorders provide challenges for development of effective medications. Use
of abused substances is likely initiated, sustained and “quit” by complex brain and …
of abused substances is likely initiated, sustained and “quit” by complex brain and …
The mechanism of covalent inhibition of LAR phosphatase by illudalic acid
DT Hansen, NJ Rueb, ND Levinzon… - Bioorganic & Medicinal …, 2024 - Elsevier
Leukocyte antigen-related (LAR) phosphatase is a receptor-type protein tyrosine
phosphatase involved in cellular signaling and associated with human disease including …
phosphatase involved in cellular signaling and associated with human disease including …
Substrate-selective positive allosteric modulation of PTPRD's phosphatase by flavonols
IM Henderson, C Marez, K Dokladny, J Smoake… - Biochemical …, 2022 - Elsevier
The receptor type protein tyrosine phosphatase D (PTPRD) is expressed by neurons and
implicated in interesting phenotypes that include reward from addictive substances, restless …
implicated in interesting phenotypes that include reward from addictive substances, restless …