The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Calcium signalling is fundamental to the function of the nervous system, in association with
changes in ionic gradients across the membrane. Although restoring ionic gradients is …

Mitochondria are dynamic organelles involved in numerous physiological functions. Beyond
their function in ATP production, mitochondria regulate cell death, reactive oxygen species …

Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major
contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is …

Rationale: Mitochondrial Ca2+ loading augments oxidative metabolism to match functional
demands during times of increased work or injury. However, mitochondrial Ca2+ overload …

Mitochondria are responsible for ATP production but are also known as regulators of cell
death, and mitochondrial matrix Ca2+ is a key modulator of both ATP production and cell …

Ca 2+ influx into mitochondria is mediated by the mitochondrial calcium uniporter (MCU),
whose identity was recently revealed as a 40-kDa protein that along with other proteins …

Mitochondrial Ca 2+ transient is the earliest discovered organellar Ca 2+ signaling pathway.
It consist of a Ca 2+ influx, mediated by mitochondrial Ca 2+ uniporter (MCU), and …

Ca2+ acts as an important cellular second messenger in eukaryotes. In both plants and
animals, a wide variety of environmental and developmental stimuli trigger Ca2+ transients …

Mitochondria contribute to cell signaling by controlling store-operated Ca2+ entry (SOCE).
SOCE is activated by Ca2+ release from the endoplasmic reticulum (ER), whereupon …