Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

PURPOSE: To analyze the available data concerning mechanisms of action of and
mechanisms of resistance to the antitubulin agents, vinca alkaloids and taxanes, and more …

Human contains 49 ATP-binding cassette (ABC) transporter genes and the multidrug
resistance associated proteins (MRP1/ABCC1, MRP2/ABCC2, MRP3/ABCC3 …

Abstract Arsenic trioxide (As2O3) induces clinical remission in acute promyelocytic leukemia
(APL) with minimal toxicity and apoptosis in APL-derived NB4 cells at low (1 to 2 μmol/L) …

The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many
drugs, glutathione S-conjugates (GS-X) of lipophilic xenobiotics and endogenous cysteinyl …