The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Traditionally, invasive coronary physiological assessment has focused on the epicardial
coronary artery. More recently, appreciation of the importance of the coronary …

In 2008, the Guidelines for diagnosis and treatment of patients with vasospastic angina
(coronary spastic angina) 1 were developed by the Japanese Circulation Society, and the …

Background: The prognostic impact of microvascular status in patients with high fractional
flow reserve (FFR) is not clear. Objectives: The goal of this study was to investigate the …

Background Diltiazem is recommended and frequently prescribed in patients with angina
and nonobstructive coronary artery disease (ANOCA), suspected of coronary vasomotor …

Objectives The aim of this study was to evaluate the diagnostic accuracy and prognostic
implications of angiography-derived index of microcirculatory resistance (angio-IMR) in …

Aims The microvascular resistance reserve (MRR) was introduced as a means to
characterize the vasodilator reserve capacity of the coronary microcirculation while …

The JACC Journals Ethics Board has voted to retract this paper, relying on the findings of
misconduct after an investigation by the University of Oxford (outlined below). The decision …

Objectives We aimed to develop a novel wire‐and adenosine‐free microcirculatory resistive
index from functional angiography (angio‐IMR) to estimate coronary microcirculatory …

The coronary microcirculation plays a pivotal role in the regulation of coronary blood flow
and cardiac metabolism. It can adapt to acute and chronic pathologic conditions such as …