[HTML][HTML] T cells in health and disease

L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Beyond immune checkpoint blockade: emerging immunological strategies

SP Kubli, T Berger, DV Araujo, LL Siu… - Nature reviews Drug …, 2021 - nature.com
The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …

Cytokine regulation and function in T cells

C Dong - Annual review of immunology, 2021 - annualreviews.org
T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …

[HTML][HTML] Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

C Cui, J Wang, E Fagerberg, PM Chen, KA Connolly… - Cell, 2021 - cell.com
Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …

[HTML][HTML] Repositioning TH cell polarization from single cytokines to complex help

S Tuzlak, AS Dejean, M Iannacone, FJ Quintana… - Nature …, 2021 - nature.com
When helper T (TH) cell polarization was initially described three decades ago, the TH cell
universe grew dramatically. New subsets were described based on their expression of few …

[HTML][HTML] Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview

C Schinocca, C Rizzo, S Fasano, G Grasso… - Frontiers in …, 2021 - frontiersin.org
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model

S Koo, HS Sohn, TH Kim, S Yang, SY Jang… - Nature …, 2023 - nature.com
Commencing with the breakdown of immune tolerance, multiple pathogenic factors,
including synovial inflammation and harmful cytokines, are conjointly involved in the …

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

V Rothhammer, FJ Quintana - Nature Reviews Immunology, 2019 - nature.com
The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …

[HTML][HTML] Intricacies of TGF-β signaling in Treg and Th17 cell biology

J Wang, X Zhao, YY Wan - Cellular & molecular immunology, 2023 - nature.com
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

[HTML][HTML] Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases

K Bunte, T Beikler - International journal of molecular sciences, 2019 - mdpi.com
Innate immunity represents the semi-specific first line of defense and provides the initial host
response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive …