Purpose The aim of this review is to assess the extent of the use of off-label and/or
unlicenced drugs among hospitalised children. Methods A systematic search was made in …

Background In the past two decades, many legislative and regulatory initiatives were taken
globally to improve drug use in children. However, children are still found to be prescribed …

Background: Given the growing use of off-label in pediatric practice, there is a growing
interest on pharmacovigilance programs monitoring the occurrence of adverse drug …

Objective: Children in PICUs normally require analgesics and sedatives to maintain comfort,
safety, and cooperation with interventions. α 2-agonists (clonidine and dexmedetomidine) …

Rational prescribing is challenging in neonatology. Drug utilization studies help identify and
define the problem. We performed a review of the literature on drug use in neonatal units …

What is known and objective The E uropean P aediatric R egulation aims to reduce off‐label
use of medicines in paediatric pharmacotherapy. Prescribing for off‐label use and …

OBJECTIVES: To characterize off-label prescribing among US pediatric intensive care units
(PICUs), determine characteristics associated with off-label use, and identify medications in …

OBJETIVO: Avaliar a frequência da prescrição de medicamentos de uso não licenciado (UL)
e off-label (OL) em recém-nascidos internados em unidade de tratamento intensivo …

BACKGROUND: Many drugs used for anesthesia and analgesia in children are
administered “off-label.” We undertook an audit of drugs commonly used for pediatric …

There was a time when the predominant approach to exposing children to new drugs was to
protect children from research. This has evolved over the past several decades into …