M Rosso, R Wirz, AV Loretan, NA Sutter… - Neuroscience & …, 2022 - Elsevier
The validity of widely used rodent behavioural tests of anxiety has been questioned, as they often fail to produce consistent results across independent replicate studies. In this study, we …
Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience …
M Ferri, M Lloyd-Evans - One Health, 2021 - Elsevier
The human coronavirus disease 2019 (COVID-19) pandemic represents one of the greatest public health crises in recent history, which has caused unprecedented and massive …
I Tomris, KM Bouwman, Y Adolfs, D Noack… - PLoS …, 2022 - journals.plos.org
SARS-CoV-2 attaches to angiotensin-converting enzyme 2 (ACE2) to gain entry into cells after which the spike protein is cleaved by the transmembrane serine protease 2 …
S Lohse - Studies in History and Philosophy of Science Part A, 2021 - Elsevier
Despite aspirations to substitute animal experimentation with alternative methods and recent progress in the area of non-animal approaches, such as organoïds and organ (s)-on-a-chip …
Q Lin, C Lu, Y Hong, R Li, J Chen, W Chen, J Chen - Antiviral Research, 2022 - Elsevier
In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly …
H Wewetzer, T Wagenknecht, B Bert, G Schönfelder - EMBO reports, 2023 - embopress.org
Modern medicine is not possible without animal testing. Whether it is the novel immunotherapies against cancer or the vaccines against SARS-CoV2, biomedical research …
The use of animals in neuroscience and biomedical research remains controversial. Policy is built around the “3R” principle of “Refining, Reducing and Replacing” animal experiments …
For most of its history, immunology has sought to control environmental variation to establish genetic causality. As with all biological traits though, variation among individuals arises by …