NOX5 is the last member of the NADPH oxidase (NOXs) family to be identified and presents
some specific characteristics differing from the rest of the NOXs. It contains four Ca2+ …

NADPH oxidases (Nox) are one of the main sources of reactive oxygen species (ROS) in the
central nervous system (CNS). While these enzymes have been shown to be involved in …

Significance: The nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzyme
family, located in the central nervous system, is recognized as a source of reactive oxygen …

Aging can cause attenuation in the functioning of multiple organs, and blood-brain barrier
(BBB) breakdown could promote the occurrence of disorders of the central nervous system …

Background To date, the pathogenesis of Alzheimer's disease is still not fully elucidated.
Much evidence suggests that Ferroptosis plays a crucial role in the pathogenesis of AD, but …

Oxidative stress is linked to the pathogenesis of Alzheimer's disease (AD), a
neurodegenerative disorder marked by memory impairment and cognitive decline. AD is …

NADPH oxidases (NOX) constitute the main reactive oxygen species (ROS) source in blood
vessels. An oxidative stress situation due to ROS overproduction can lead into endothelial …

Obesity is a global health issue associated with the development of metabolic syndrome,
which correlates with insulin resistance, altered lipid homeostasis, and other pathologies …

The NOX family consists of seven isoenzymes that produce reactive oxygen species (ROS)
from molecular oxygen. Changes in redox balance may impact disorders linked to metabolic …

Human life expectancy has been significantly extended, which poses major challenges to
our healthcare and social systems. Aging-associated cognitive impairment is attributed to …