This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Allergies are rapidly worsening in recent decades, representing the most common
immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis …

Biological sex impacts disease prevalence, severity and response to therapy in asthma,
however preclinical studies often use only one sex in murine models. Here, we detail sex …

Asthma is a chronic inflammatory disease characterized by variable airflow limitation and
airway hyperresponsiveness. A plethora of immune and structural cells are involved in …

There is good evidence for gender-specific differences in asthma regarding all affected
areas, from intra-to extra-cellular mediators to the whole organ structure und functioning of …

A multitude of evidence has suggested the differential incidence, prevalence and severity of
asthma between males and females. A compilation of recent literature recognized sex …

Epidemiological data suggests increased prevalence of asthma in females than males,
suggesting a plausible role for sex-steroids, especially estrogen in the lungs. Estrogen …

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Evidence suggests that airway hyperresponsiveness (AHR) is a characteristic feature of
asthma. Epidemiological studies have confirmed that the severity of asthma is greater in …

The noninvasive diagnosis and monitoring of high prevalence diseases such as
cardiovascular diseases, cancers and chronic respiratory diseases are currently priority …