Mechanism of interferon alpha therapy for chronic hepatitis B and potential approaches to improve its therapeutic efficacy
Hepatitis B virus (HBV) chronically infects 296 million people worldwide and causes more
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
than 820,000 deaths annually due to cirrhosis and hepatocellular carcinoma. Current …
Revisiting hepatitis B virus: challenges of curative therapies
With a yearly death toll of 880,000, hepatitis B virus (HBV) remains a major health problem
worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals …
worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals …
Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels
C Ko, A Chakraborty, WM Chou, J Hasreiter… - Journal of …, 2018 - Elsevier
Background & Aims Several steps in the HBV life cycle remain obscure because of a lack of
robust in vitro infection models. These steps include particle entry, formation and …
robust in vitro infection models. These steps include particle entry, formation and …
[HTML][HTML] Antiviral activity, safety, and pharmacokinetics of capsid assembly modulator NVR 3-778 in patients with chronic HBV infection
Background & Aims NVR 3-778 is a first-in-class hepatitis B virus (HBV) capsid assembly
modulator that can inhibit HBV replication. We performed a proof-of-concept study to …
modulator that can inhibit HBV replication. We performed a proof-of-concept study to …
Capsid assembly modulators as antiviral agents against HBV: molecular mechanisms and clinical perspectives
Despite a preventive vaccine being available, more than 250 million people suffer from
chronic hepatitis B virus (HBV) infection, a major cause of liver disease and HCC. HBV …
chronic hepatitis B virus (HBV) infection, a major cause of liver disease and HCC. HBV …
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
JNJ-56136379, an HBV capsid assembly modulator, is well-tolerated and has antiviral activity in a phase 1 study of patients with chronic infection
Background & Aims JNJ-56136379 (JNJ-6379), a capsid assembly modulator that blocks
hepatitis B virus (HBV) replication, was well tolerated and demonstrated dose-proportional …
hepatitis B virus (HBV) replication, was well tolerated and demonstrated dose-proportional …
Prospects for the global elimination of hepatitis B
Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
Discovery of a first-in-class orally available HBV cccDNA inhibitor
Background & Aims The persistence of covalently closed circular DNA (cccDNA) in infected
hepatocytes is the major barrier preventing viral eradication with existing therapies in …
hepatocytes is the major barrier preventing viral eradication with existing therapies in …
Novel potent capsid assembly modulators regulate multiple steps of the hepatitis B virus life cycle
T Lahlali, JM Berke, K Vergauwen, A Foca… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The assembly of hepatitis B virus (HBV) core protein (HBc) into capsids represents a critical
step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it …
step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it …