Uric acid, once viewed as an inert metabolic end-product of purine metabolism, has been
recently incriminated in a number of chronic disease states, including hypertension …

Background Hyperuricemia has been reported to be associated with chronic kidney disease
(CKD). However whether an elevated serum uric acid level is an independent risk factor for …

Metabolic syndrome represents a collection of abnormalities that includes fatty liver, and it
currently affects one-third of the United States population and has become a major health …

Prehypertension frequently progresses to hypertension, a condition associated with high
morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors …

This review summarizes relevant studies concerning uric acid and possible links to
hypertension, renal disease, and cardiovascular disease. Whether uric acid is an …

Background Hyperuricemia is a putative risk factor for the progression of chronic kidney
disease (CKD). We hypothesized that control of asymptomatic hyperuricemia may slow …

Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly
considered a true risk factor. Recent studies suggest that uric acid is biologically active and …

Effect of Allopurinol in Chronic Kidney Disease Progression... : Clinical Journal of the
American Society of Nephrology Effect of Allopurinol in Chronic Kidney Disease …

Background Asymptomatic hyperuricemia increases renal and cardiovascular (CV) risk. We
previously conducted a 2-year, single-blind, randomized, controlled trial of allopurinol …

The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …