Implications of peptide assemblies in amyloid diseases
Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …
quality of life of millions worldwide, with profound social and economic implications. Despite …
Type 2 diabetes as a protein misfolding disease
A Mukherjee, D Morales-Scheihing, PC Butler… - Trends in molecular …, 2015 - cell.com
Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …
Lipid-chaperone hypothesis: A common molecular mechanism of membrane disruption by intrinsically disordered proteins
An increasing number of human diseases has been shown to be linked to aggregation and
amyloid formation by intrinsically disordered proteins (IDPs). Amylin, amyloid-β, and α …
amyloid formation by intrinsically disordered proteins (IDPs). Amylin, amyloid-β, and α …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Amyloid assembly and disassembly
E Chuang, AM Hori, CD Hesketh… - Journal of Cell …, 2018 - journals.biologists.com
Amyloid fibrils are protein homopolymers that adopt diverse cross-β conformations. Some
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …
amyloid fibrils are associated with the pathogenesis of devastating neurodegenerative …
Islet amyloid polypeptide: structure, function, and pathophysiology
R Akter, P Cao, H Noor, Z Ridgway… - Journal of diabetes …, 2016 - Wiley Online Library
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
The activity of peptides of the calcitonin family in bone
Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating
calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as …
calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as …
The β-cell assassin: IAPP cytotoxicity
Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …
Islet amyloid polypeptide membrane interactions: effects of membrane composition
Amyloid formation by islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …
[HTML][HTML] IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies
Islet amyloid polypeptide (aka IAPP, amylin) is a 37 amino acid hormone that has long been
associated with the progression of type II diabetes mellitus (TIIDM) disease. The endocrine …
associated with the progression of type II diabetes mellitus (TIIDM) disease. The endocrine …