[HTML][HTML] Toxicity of metal-based nanoparticles: Challenges in the nano era

N Zhang, G Xiong, Z Liu - Frontiers in Bioengineering and …, 2022 - frontiersin.org
With the rapid progress of nanotechnology, various nanoparticles (NPs) have been
applicated in our daily life. In the field of nanotechnology, metal-based NPs are an important …

Ferroptosis as a mechanism of non-ferrous metal toxicity

M Aschner, AV Skalny, AC Martins, AI Sinitskii… - Archives of …, 2022 - Springer
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple
pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron …

Copper induces oxidative stress and apoptosis through mitochondria-mediated pathway in chicken hepatocytes

F Yang, R Pei, Z Zhang, J Liao, W Yu, N Qiao, Q Han… - Toxicology in Vitro, 2019 - Elsevier
The aim of this study was to investigate the effects of excessive copper (Cu)-induced
cytotoxicity on oxidative stress and mitochondrial apoptosis in chicken hepatocytes. Chicken …

[HTML][HTML] Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1)

G Gupta, F Cappellini, L Farcal, R Gornati… - Particle and Fibre …, 2022 - Springer
Abstract Background Copper oxide (CuO) nanoparticles (NPs) are known to trigger
cytotoxicity in a variety of cell models, but the mechanism of cell death remains unknown …

Fabrication of graphene oxide/copper synergistic antibacterial coating for medical titanium substrate

F Yang, D Huo, J Zhang, T Lin, J Zhang, S Tan… - Journal of Colloid and …, 2023 - Elsevier
Titanium (Ti) was an excellent medical metal material, but the lack of good antibacterial
activity confined its further practical application. To solve this dilemma, a coating containing …

Proteomics revealed the crosstalk between copper stress and cuproptosis, and explored the feasibility of curcumin as anticancer copper ionophore

Y Yang, S Liang, H Geng, M Xiong, M Li, Q Su… - Free Radical Biology …, 2022 - Elsevier
As an essential micronutrient element in organisms, copper controls a host of fundamental
cellular functions. Recently, copper-dependent cell growth and proliferation have been …

Copper induces oxidative stress and apoptosis in the mouse liver

H Liu, H Guo, Z Jian, H Cui, J Fang… - Oxidative medicine …, 2020 - Wiley Online Library
Copper (Cu) is an essential trace element involved in the normal physiological processes of
animals. However, excessive exposure to Cu can produce numerous detrimental impacts …

Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes

F Yang, J Liao, R Pei, W Yu, Q Han, Y Li, J Guo, L Hu… - Chemosphere, 2018 - Elsevier
Copper (Cu) is an essential trace element that is required for the catalysis of several cellular
enzymes. Excessive Cu could induce hepatotoxicity in humans and multiple animals. The …

Cu-induced spermatogenesis disease is related to oxidative stress-mediated germ cell apoptosis and DNA damage

H Guo, Y Ouyang, J Wang, H Cui, H Deng… - Journal of Hazardous …, 2021 - Elsevier
Copper is considered as an indispensable trace element for living organisms. However,
over-exposure to Cu can lead to adverse health effects on human. In this study, CuSO 4 …

Copper induces spleen damage through modulation of oxidative stress, apoptosis, DNA damage, and inflammation

H Guo, Y Wang, H Cui, Y Ouyang, T Yang, C Liu… - … Trace Element Research, 2022 - Springer
Copper (Cu) is an essential micronutrient for both humans and animals; however, excessive
intake of Cu can be immunotoxic. There are limited studies on spleen toxicity induced by Cu …