Prophages provide a rich source of antiphage defense systems

PH Patel, KL Maxwell - Current Opinion in Microbiology, 2023 - Elsevier
Temperate phages are pervasive in nature, existing within bacterial cells in a form known as
prophages. In this state, survival of the phage is intricately tied to the survival of the bacterial …

The diverse impacts of phage morons on bacterial fitness and virulence

VL Taylor, AD Fitzpatrick, Z Islam, KL Maxwell - Advances in virus research, 2019 - Elsevier
The viruses that infect bacteria, known as phages, are the most abundant biological entity on
earth. They play critical roles in controlling bacterial populations through phage-mediated …

INfrastructure for a PHAge REference database: identification of large-scale biases in the current collection of cultured phage genomes

R Cook, N Brown, T Redgwell, B Rihtman, M Barnes… - Phage, 2021 - liebertpub.com
Background: With advances in sequencing technology and decreasing costs, the number of
phage genomes that have been sequenced has increased markedly in the past decade …

[HTML][HTML] Prophages encode phage-defense systems with cognate self-immunity

SV Owen, N Wenner, CL Dulberger, EV Rodwell… - Cell host & …, 2021 - cell.com
Temperate phages are pervasive in bacterial genomes, existing as vertically inherited
islands termed prophages. Prophages are vulnerable to predation of their host bacterium by …

Anti-phage defence through inhibition of virion assembly

PH Patel, VL Taylor, C Zhang, LJ Getz… - Nature …, 2024 - nature.com
Bacteria have evolved diverse antiviral defence mechanisms to protect themselves against
phage infection. Phages integrated into bacterial chromosomes, known as prophages, also …

A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa

M Shah, VL Taylor, D Bona, Y Tsao, SY Stanley… - Molecular Cell, 2021 - cell.com
The arms race between bacteria and phages has led to the evolution of diverse anti-phage
defenses, several of which are controlled by quorum-sensing pathways. In this work, we …

A filamentous bacteriophage protein inhibits type IV pili to prevent superinfection of Pseudomonas aeruginosa

AK Schmidt, AD Fitzpatrick, CM Schwartzkopf, DR Faith… - MBio, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen that causes infections in a variety of
settings. Many P. aeruginosa isolates are infected by filamentous Pf bacteriophage …

Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22

A Fillol-Salom, R Bacigalupe, S Humphrey… - Nature …, 2021 - nature.com
Lysogenic induction ends the stable association between a bacteriophage and its host, and
the transition to the lytic cycle begins with early prophage e xcision followed by DNA r …

Pf bacteriophage and their impact on Pseudomonas virulence, mammalian immunity, and chronic infections

PR Secor, EB Burgener, M Kinnersley… - Frontiers in …, 2020 - frontiersin.org
Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa,
a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and …

Bacteriophages as drivers of bacterial virulence and their potential for biotechnological exploitation

K Schroven, A Aertsen, R Lavigne - FEMS microbiology reviews, 2021 - academic.oup.com
Bacteria-infecting viruses (phages) and their hosts maintain an ancient and complex
relationship. Bacterial predation by lytic phages drives an ongoing phage-host arms race …