Genetics of healthy aging and longevity
AR Brooks-Wilson - Human genetics, 2013 - Springer
Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …
The network and the remodeling theories of aging: historical background and new perspectives
Two general theories, ie “the network theory of aging”(1989) and “the remodeling theory of
aging”(1995), as well as their implications, new developments, and perspectives are …
aging”(1995), as well as their implications, new developments, and perspectives are …
Association of human aging with a functional variant of klotho
DE Arking, A Krebsova, M Macek Sr… - Proceedings of the …, 2002 - National Acad Sciences
Mice deficient in Klotho gene expression exhibit a syndrome resembling premature human
aging. To determine whether variation in the human KLOTHO locus contributes to survival …
aging. To determine whether variation in the human KLOTHO locus contributes to survival …
Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging
Circulating microRNAs (miRs) have been investigated as diagnostic/prognostic biomarkers
in human diseases. However, little is known about their expression throughout the aging …
in human diseases. However, little is known about their expression throughout the aging …
Centenarians: An excellent example of resilience for successful ageing
Centenarians are remarkable not only because of their prolonged life, but also because they
compress morbidity until the very last moments of their lives, thus being proposed as a …
compress morbidity until the very last moments of their lives, thus being proposed as a …
Immunosenescence and immunogenetics of human longevity
R Ostan, L Bucci, M Capri, S Salvioli, M Scurti… - …, 2008 - karger.com
At present, individuals can live up to 80–120 years, a time much longer than that of our
ancestors, as a consequence of the improvements in life conditions and medical care. Thus …
ancestors, as a consequence of the improvements in life conditions and medical care. Thus …
The genetics of human longevity: an intricacy of genes, environment, culture and microbiome
Approximately one-quarter of the variation in lifespan in developed countries can be
attributed to genetic factors. However, even large population based studies investigating …
attributed to genetic factors. However, even large population based studies investigating …
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the …
In this paper, we review data of recent literature on the distribution in centenarians of
candidate germ-line polymorphisms that likely affect the individual chance to reach the …
candidate germ-line polymorphisms that likely affect the individual chance to reach the …
The genetics of human longevity
M Capri, S Salvioli, F Sevini, S Valensin… - Annals of the New …, 2006 - Wiley Online Library
Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a
strong genetic component appears to have an impact on survival to extreme ages. In order …
strong genetic component appears to have an impact on survival to extreme ages. In order …
Genetic determinants of human health span and life span: progress and new opportunities
We review three approaches to the genetic analysis of the biology and pathobiology of
human aging. The first and so far the best-developed is the search for the biochemical …
human aging. The first and so far the best-developed is the search for the biochemical …