Hepatitis C virus (HCV) replication requires annealing of a liver specific microRNA, miR-122
to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene …

Non-alcoholic fatty liver disease (NAFLD) is defined as a pathologic accumulation of fat in
the form of triglycerides (TG) in the liver (steatosis) that is not caused by alcohol. A subgroup …

Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities;
however, the molecular consequences of ZIKV to human brain development are still not fully …

ABSTRACT miR-122 is a liver-specific microRNA (miRNA) that binds to two sites (S1 and
S2) on the 5′ untranslated region (UTR) of the hepatitis C virus (HCV) genome and …

Translation of the hepatitis C virus (HCV) RNA genome is regulated by the internal ribosome
entry site (IRES), located in the 5'-untranslated region (5′ UTR) and part of the core protein …

RNA granules are dynamic cellular structures essential for proper gene expression and
homeostasis. The two principal types of cytoplasmic RNA granules are stress granules …

DEAD-box RNA helicases, the largest family of superfamily 2 helicases, are a profoundly
conserved family of RNA-binding proteins, containing a distinctive Asp–Glu–Ala–Asp …

The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs)
to avoid inappropriate expression. Pathological ISG activation resulting from aberrant …

The hepatitis C virus (HCV), an obligatory intracellular pathogen, highly depends on its host
cells to propagate successfully. The HCV life cycle can be simply divided into several stages …

The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly
understood. Here, we identify a novel and highly conserved mechanism of translational …