Apoptosis and necroptosis in the liver: a matter of life and death

RF Schwabe, T Luedde - Nature reviews Gastroenterology & …, 2018 - nature.com
Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Changes in glutathione content in liver diseases: an update

M Vairetti, LG Di Pasqua, M Cagna, P Richelmi… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Association of inflammatory cytokines with non-alcoholic fatty liver disease

Y Duan, X Pan, J Luo, X Xiao, J Li… - Frontiers in …, 2022 - frontiersin.org
Background Inflammatory cytokines have been considered to be significant factors
contributing to the development and progression of non-alcoholic fatty liver disease …

Antioxidant peptides from monkfish swim bladders: ameliorating NAFLD in vitro by suppressing lipid accumulation and oxidative stress via regulating AMPK/Nrf2 …

MF Wu, QH Xi, Y Sheng, YM Wang, WY Wang, CF Chi… - Marine drugs, 2023 - mdpi.com
In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8),
DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on …

Oxidative stress and non-alcoholic fatty liver disease: effects of omega-3 fatty acid supplementation

J Yang, M Fernández-Galilea, L Martínez-Fernández… - Nutrients, 2019 - mdpi.com
Aging is a complex phenomenon characterized by the progressive loss of tissue and organ
function. The oxidative-stress theory of aging postulates that age-associated functional …

Inflammation is a major regulator of drug metabolizing enzymes and transporters: consequences for the personalization of drug treatment

F Stanke-Labesque, E Gautier-Veyret, S Chhun… - Pharmacology & …, 2020 - Elsevier
Inflammation is an evolutionary process that allows survival against acute infection or injury.
Inflammation is also a pathophysiological condition shared by numerous chronic diseases …

Relevance of SIRT1-NF-κB axis as therapeutic target to ameliorate inflammation in liver disease

E de Gregorio, A Colell, A Morales, M Marí - International journal of …, 2020 - mdpi.com
Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease

J Wang, W He, PJ Tsai, PH Chen, M Ye, J Guo… - Lipids in Health and …, 2020 - Springer
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances
between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is …

[HTML][HTML] A new perspective on NAFLD: Focusing on the crosstalk between peroxisome proliferator-activated receptor alpha (PPARα) and farnesoid X receptor (FXR)

S Zhou, H You, S Qiu, D Yu, Y Bai, J He, H Cao… - Biomedicine & …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

As we drink and breathe: Adverse health effects of microcystins and other harmful algal bloom toxins in the liver, gut, lungs and beyond

A Lad, JD Breidenbach, RC Su, J Murray, R Kuang… - Life, 2022 - mdpi.com
Freshwater harmful algal blooms (HABs) are increasing in number and severity worldwide.
These HABs are chiefly composed of one or more species of cyanobacteria, also known as …