Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
P Lisowski, S Lickfett, A Rybak-Wolf… - Nature …, 2024 - nature.com
Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the
neurodegenerative disorder Huntington's disease (HD). Emerging evidence suggests that …
neurodegenerative disorder Huntington's disease (HD). Emerging evidence suggests that …
[HTML][HTML] Memantine suppresses the excitotoxicity but fails to rescue the ataxic phenotype in SCA1 model mice
OS Belozor, A Vasilev, AG Mileiko, LD Mosina… - Biomedicine & …, 2024 - Elsevier
Abstract Spinocerebellar ataxia type 1 (SCA1) is a debilitating neurodegenerative disorder
of the cerebellum and brainstem. Memantine has been proposed as a potential treatment for …
of the cerebellum and brainstem. Memantine has been proposed as a potential treatment for …