Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

L Zhao, S Jin, S Wang, Z Zhang, X Wang… - … and Targeted Therapy, 2024 - nature.com
Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Tertiary lymphoid structures and cytokines interconnections: the implication in cancer immunotherapy

H Li, JY Ding, MJ Zhang, HJ Yu, ZJ Sun - Cancer Letters, 2023 - Elsevier
Tertiary lymphoid structures (TLSs) are organized aggregates of lymphocytes and antigen-
presenting cells that develop in non-lymphoid tissues during chronic inflammation …

[PDF][PDF] One year in review 2020: pathogenesis of primary Sjögren's syndrome

M Bombardieri, OD Argyropoulou, F Ferro… - Clin Exp …, 2020 - clinexprheumatol.org
The pathogenesis of primary Sjögren's syndrome (pSS) remains poorly understood.
However, important efforts have been made during the last few months. In this review …

Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren's syndrome

N Kaneko, H Chen, CA Perugino, T Maehara… - Scientific reports, 2022 - nature.com
Sjögren's syndrome is a chronic autoimmune disorder whose pathogenesis is poorly
understood and that lacks effective therapies. Detailed quantitative and spatial analyses of …

Tertiary lymphoid structures in pancreatic cancer: a new target for immunotherapy

X Zou, C Guan, J Gao, W Shi, Y Cui… - Frontiers in …, 2023 - frontiersin.org
Pancreatic cancer (PC) is extremely malignant and shows limited response to available
immunotherapies due to the hypoxic and immunosuppressive nature of its tumor …

New frontiers in precision medicine for Sjogren's syndrome

L Chatzis, PG Vlachoyiannopoulos… - Expert review of …, 2021 - Taylor & Francis
Introduction: Sjögren's syndrome is a unique systemic autoimmune disease, placed in the
center of systemic autoimmunity and at the crossroads of autoimmunity and …

Tertiary lymphoid structures in autoimmune diseases

Y Dong, T Wang, H Wu - Frontiers in Immunology, 2024 - frontiersin.org
Tertiary lymphoid structures (TLSs) are organized lymphoid-like aggregations in non-
lymphoid tissues. Tissues with chronic and persistent inflammation infiltration may drive and …

Cellular and molecular diversity in Sjogren's syndrome salivary glands: Towards a better definition of disease subsets

E Pontarini, R Coleby, M Bombardieri - Seminars in Immunology, 2021 - Elsevier
Primary Sjögren's syndrome (pSS) is a highly heterogeneous disease in terms of clinical
presentation ranging from a mild disease localised to the salivary and lacrimal glands, to …

Tertiary lymphatic structures in primary hepatic carcinoma: controversy cannot overshadow hope

W Jia, T Zhang, Q Yao, J Li, Y Nie, X Lei… - Frontiers in …, 2022 - frontiersin.org
Tertiary lymphoid structures (TLSs) are organized aggregates of immune cells found in the
tumor microenvironment. TLS can influence primary hepatic carcinoma (PHC) occurrence …

Making sense of IL‐6 signalling cues in pathophysiology

D Millrine, RH Jenkins, STO Hughes, SA Jones - FEBS letters, 2022 - Wiley Online Library
Unravelling the molecular mechanisms that account for functional pleiotropy is a major
challenge for researchers in cytokine biology. Cytokine–receptor cross‐reactivity and shared …