With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Proteins synthesized in the endoplasmic reticulum (ER) are properly folded with the
assistance of ER chaperones. Malfolded proteins are disposed of by ER‐associated protein …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Huntington's disease (HD) is an incurable neurodegenerative disease characterized by
abnormal motor movements, personality changes, and early death. HD is caused by a …

Many neurodegenerative disorders are characterized by conformational changes in proteins
that result in misfolding, aggregation and intra-or extra-neuronal accumulation of amyloid …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

The list of developmental and degenerative diseases that are caused by expansion of
unstable repeats continues to grow, and is now approaching 20 disorders. The pathogenic …

Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

Misfolding and aggregation are associated with cytotoxicity in several protein folding
diseases. A large network of molecular chaperones ensures protein quality control. Here, we …