Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting
epigenetic abnormality is a new strategy for cancer therapy. Understanding how …

O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …

Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an
important function in diverse biological processes and diseases. However, the roles of Ogt in …

Repeated exposure to opioids causes tolerance, which limits their analgesic utility and
contributes to overdose and abuse liability. However, the molecular mechanisms …

Neurotransmitters like dopamine (DA), serotonin (SRT), γ-aminobutyric acid (GABA) and
acetylcholine (ACh) are messenger molecules that play a pivotal role in transmitting …

GNAO1 encephalopathy is a neurodevelopmental disorder with a spectrum of symptoms
that include dystonic movements, seizures and developmental delay. While numerous …

Glycosyltransferase OGT catalyzes the conjugation of O-linked β-DN-acetylglucosamine (O-
GlcNAc) to Ser and Thr residues of the cellular proteins and regulates many key processes …

Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we
explore the growing importance of Huwe1 in nervous system development, function and …

The conserved O-GlcNAc transferase OGT O-GlcNAcylates serine and threonine residues of
intracellular proteins to regulate their function. OGT is required for viability in mammalian …