Global and local environmental changes as drivers of Buruli ulcer emergence: Environmental changes and infectious disease

M Combe, CJ Velvin, A Morris… - Emerging microbes & …, 2017 - Taylor & Francis
Many emerging infectious diseases are caused by generalist pathogens that infect and
transmit via multiple host species with multiple dissemination routes, thus confounding the …

A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain

S Muhi, J Osowicki, D O'Brien… - PLOS Neglected …, 2023 - journals.plos.org
Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of
Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines …

Geographic distribution, age pattern and sites of lesions in a cohort of Buruli ulcer patients from the Mapé Basin of Cameroon

MW Bratschi, M Bolz, JC Minyem, L Grize… - PLoS neglected …, 2013 - journals.plos.org
Buruli ulcer (BU), a neglected tropical disease of the skin, caused by Mycobacterium
ulcerans, occurs most frequently in children in West Africa. Risk factors for BU include …

The changing epidemiology worldwide of Mycobacterium ulcerans

DP O'Brien, I Jeanne, K Blasdell… - Epidemiology & …, 2019 - cambridge.org
Mycobacterium ulcerans is recognised as the third most common mycobacterial infection
worldwide. It causes necrotising infections of skin and soft tissue and is classified as a …

Mycobacterium ulcerans Ecological Dynamics and Its Association with Freshwater Ecosystems and Aquatic Communities: Results from a 12-Month Environmental …

A Garchitorena, B Roche, R Kamgang… - PLoS neglected …, 2014 - journals.plos.org
Background Mycobacterium ulcerans (MU) is the agent responsible for Buruli Ulcer (BU), an
emerging skin disease with dramatic socioeconomic and health outcomes, especially in …

Seroprevalence of pertussis in China: need to improve vaccination strategies

YH Xu, L Wang, J Xu, X Wang, C Wei… - Human vaccines & …, 2014 - Taylor & Francis
Pertussis remains an important cause of infant death worldwide and is an ongoing public
health concern even in countries with high vaccination coverage. A cross-sectional …

Clinical and laboratory diagnosis of Buruli ulcer disease: a systematic review

SA Sakyi, SY Aboagye, I Darko Otchere… - Canadian Journal of …, 2016 - Wiley Online Library
Background. Buruli ulcer (BU) is a necrotizing cutaneous infection caused by
Mycobacterium ulcerans. Early diagnosis is crucial to prevent morbid effects and misuse of …

[PDF][PDF] Laboratory diagnosis of Buruli ulcer: challenges and future perspectives

K Röltgen, I Cruz, JM Ndung'u… - Buruli ulcer …, 2019 - library.oapen.org
The clinical presentation of Buruli ulcer (BU) is manifold and includes relatively unspecific,
non-ulcerative manifestations such as nodules, papules, plaques, and edema, which may …

Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice

R Bieri, M Bolz, MT Ruf, G Pluschke - PLoS neglected tropical …, 2016 - journals.plos.org
Buruli ulcer (BU), caused by infection with Mycobacterium ulcerans, is a chronic necrotizing
human skin disease associated with the production of the cytotoxic macrolide exotoxin …

Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms

S Bibert, MW Bratschi, SY Aboagye, E Collinet… - Frontiers in …, 2017 - frontiersin.org
Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue.
The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin …