Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Malaria vaccine development entered a new era in 2015 when the pre-erythrocytic
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …

A highly protective malaria vaccine would greatly facilitate the prevention and elimination of
malaria and containment of drug-resistant parasites. A high level (more than 90%) of …

The global decline in malaria has stalled, emphasizing the need for vaccines that induce
durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination …

The presentation of exogenous antigens on MHC class I molecules, known as cross-
presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross …

Summary Background Plasmodium falciparum sporozite (PfSPZ) Vaccine is a metabolically
active, non-replicating, whole malaria sporozoite vaccine that has been reported to be safe …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Consistent, high-level, vaccine-induced protection against human malaria has only been
achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites …

Recent evidence suggests that certain vaccines, including Bacillus-Calmette Guérin (BCG),
can induce changes in the innate immune system with non-specific memory characteristics …

Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …